A practice oriented, interactive platform to promote Replacement, Reduction and Refinement in animal experiments.
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May 12, 2017

Animal Free Research: Call for project proposals
The overall aim of the funding opportunity is to support researchers who want to develop and/or implement a 3R-relevant project. The focus lies on replacement/reduction.
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May 12, 2017

22.5.2017 Prof. Dr. Gerald Schwank
Organe aus dem Reagenzglas - Nutzen für Mensch und Tier Prof. Dr.
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April 10, 2017

Optimizing reliability of mouse performance in behavioral testing
The major role of non-aversive handling Abstract: Handling laboratory animals during test procedures is an important source of stress that may impair reliability of test responses. Picking up mice by the tail is aversive, stimulating stress and anxiety.
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April 10, 2017

N3CR News: How serious are we about asepsis for rodent surgery?
The National Centre for the Replacement, Refinement & Reduction of animal Research (NC3R) has recently published a blog from Prof. Paul Flecknell, Newcastle University on the issue of aseptic surgery.
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April 10, 2017

NC3R News: 10 ways your 3R funding application could be failing.
To help applicants avoid common pitfalls encountered during application process for 3R projects, the top ten tips were gathered by the NC3R funding team and panel members. Top ten tips for successful application.
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January 17, 2017

Surgical practice without live animal - Registration is now open!
This new course of surgical practice is organized by WASP science (Without Animal Suffering and Pain) and takes place from March 15 to 17 in Lyon. Intended for technicians and researchers, it is essentially practical and accommodates no more than 12 people.
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January 3, 2017

3R World Congress 2017
Tenth World Congress - Alternatives and animal use in Life Sciences Seattle, Washington, USA Save the Date for The 3Rs in Action! August 20-24, 2017  

December 19, 2016

Do you know...ALTEX?
ALTEX is devoted to the publication of research on the development and promotion of alternatives to animal experiments according to the 3Rs concept of Russell and Burch: Replace, Reduce, and Refine. ALTEX publishes original articles, short communications, and reviews, as well as news and comments, meeting reports, and book reviews.
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December 19, 2016

40 years Animalfree Research
Animal Free Research is a society for animal welfare as highest priority. It was founded in 1976 by Susi Goll and Irene Hagmann with the motivation is to replace animal experiments.
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July 1, 2016

Electroencephalographic responses to tail clamping in anaesthetized rat pups
The authors investigated electroencephalographic (EEG) responses to tail clamping in lightly anaesthetized rat pups (5–22 days) in order to determine the ontogeny of EEG activity and at what age they may be capable of experiencing pain. Median frequency (F50) and spectral edge frequency (F95) of the power spectrum in the range of 1–30 Hz were determined before and after the application of a noxious stimulus and power spectra were compared by multivariate analysis.
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July 1, 2016

Comparative analysis and physiological impact of different tissue biopsy methodologies used for the genotyping of laboratory mice
Genotyping of genetically modified mice and control of authenticity of the genetic background of congenic or coisogenic strains by polymerase chain reaction (PCR) is a routine procedure that can be performed with different tissue biopsies causing variable grades of trauma. In this study, some invasive and non-invasive sampling methods were compared, with the main focus on the impact on animal physiology.
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April 25, 2016

The AAALAC Global 3Rs Awards program
The Global 3Rs Awards program recognizes significant innovative contributions toward the 3Rs of animal research to advance ethical science, by any researcher (nominated author, principal investigator, or research team leader), in academia or industry in any area of biology (e.g.
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April 13, 2016

The Animal Research Behind The Top 25 Most Prescribed Drugs
View list here.    

April 13, 2016

Use of hydrophobic sand in collection of analytical urine samples
Smith and colleagues presented a new method for the collection of urine samples with the potential to reduce time, costs, animal stress and improve animal welfare. Read the full poster here (PDF).
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February 26, 2016

Applying refinement to the use of mice and rats in rheumatoid arthritis research
Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo studies, which have the potential to cause discomfort, pain or distress.
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February 26, 2016

Why We Need Blind Data Recording
Observer bias and other "experimenter effects" occur when researchers' expectations influence study outcome. These biases are strongest when researchers expect a particular result, are measuring subjective variables, and have an incentive to produce data that confirm predictions.
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January 15, 2015

Improving intravenous injection in black mice
Intravenous injection in black mice is difficult because the lateral tail vein used faintly contrasts to the skin. Here, an improved injection protocol is presented.
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January 8, 2015

Using body temperature, food and water consumption as biomarkers of disease progression in mice with Eµ-myc lymphoma
Non-invasive biomarkers of disease progression in mice with cancer are lacking, making it challenging to implement appropriate humane end points. The authors conclude that temperature, food and water consumption were useful biomarkers of disease progression in mice with lymphomas and could potentially be used more widely to monitor mice with other forms of cancer.
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