The Global 3Rs Awards program recognizes significant innovative contributions toward the 3Rs of animal research to advance ethical science, by any researcher (nominated author, principal investigator, or research team leader), in academia or industry in any area of biology (e.g., basic science, discovery, development, teaching, testing, manufacture for new medicines, vaccines, medical devices or healthcare products […]
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Smith and colleagues presented a new method for the collection of urine samples with the potential to reduce time, costs, animal stress and improve animal welfare. Read the full poster here (PDF).
New or improved therapies and treatments are needed for Rheumatoid arthritis (RA) and in vivo studies are part of the research and development process. This document complements the literature on good practice within RA research by providing practical infor-mation on refinement that is often not included in publications.
In scientific research, our expectations can strongly influence the results of experiments. In this paper the authors discuss the importance of randomizing scientific experiments to avoid bias.
The protocol describes an improved (refined) method for tail vein injection in black mice using a combination of a special LED illumination, a Broome style restrainer as well as effortless insulin syringes.
Non-invasive biomarkers of disease progression in mice with cancer are lacking, making it challenging to implement appropriate humane end points. The authors conclude that temperature, food and water consumption were useful biomarkers of disease progression in mice with lymphomas and could potentially be used more widely to monitor mice with other forms of cancer.
The authors propose to modify current research policies. In particular they propose to discourage the common use of exploratory studies to support confirmatory inferences, but to 1) promote a greater volume of confirmatory investigations, and 2) to customize design and reporting guidelines for each mode.
The article focuses on the possibilities of reducing the number of animals by skipping small animal models, by evidence based selection of animal models and by choosing characteristics that increase their predictive value.
Please learn to know SYRCLE: It stands for Systematic Review Centre for Laboratory Animal Experimentation.