Are you aware of PREPARE?

As part of ongoing efforts to reduce the number of animals and increase reproducibility of animal research, a group of experts led by the Secretary of Norecopa (Norway´s National Consensus Platform for the advancement of the 3R´s) has produced a set of guidelines for planning animal experiments:



(Planning Research and Experimental Procedures on Animals: Recommendations for Excellence)


These guidelines for planning animal experiments complement the ARRIVE ( guidelines and other guidance for reporting experiments. PREPARE focuses on a large number of factors which, although they are seldom reported in scientific papers, can dramatically influence the validity and the outcome of studies using animals,. They cover all stages of quality assurance, from the management of an animal facility to the individual procedures, which form part of a study. The guidelines are based upon the authors´ experience in running animal facilities, collaborating with researchers (including those working with farm animals, fish and wildlife), serving on advisory and regulatory committees, and planning their own animal studies. They are a good starting point for everyone planning to do experiments requiring animals.


Download guidelines here:

Smith, AJ, Clutton, RE, Lilley, E, Hansen KEAa, Brattelid, T.  PREPARE: Guidelines for planning animal research and testing. Laboratory Animals. Prepublished 3 August 2017


In the article where Smith and colleagues introduce the guidelines they discuss in detail the 15 topics, with a large number of links to other more specific resources. They include a suggestion for a contract between the animal facility and research group, to aid division of labour, costs and responsibility.

A 2-page checklist, available in several languages, can be downloaded here.