The authors propose to modify current research policies. In particular they propose to discourage the common use of exploratory studies to support confirmatory inferences, but to 1) promote a greater volume of confirmatory investigations, and 2) to customize design and reporting guidelines for each mode.
The article focuses on the possibilities of reducing the number of animals by skipping small animal models, by evidence based selection of animal models and by choosing characteristics that increase their predictive value.
In this provocative essay the author, John P.A. Ioannidis, examines and discusses the increasing concern that many published research findings are false.
The Rectors Conference of the Swiss Universities (CRUS) has issued principles regarding animal experimentation (adopted 17/01/2013).