Blog - Category: Termination Criteria/Score

Using body temperature, food and water consumption as biomarkers of disease progression in mice with Eµ-myc lymphoma

Non-invasive biomarkers of disease progression in mice with cancer are lacking, making it challenging to implement appropriate humane end points. The authors conclude that temperature, food and water consumption were useful biomarkers of disease progression in mice with lymphomas and could potentially be used more widely to monitor mice with other forms of cancer.

University of Virginia Guidelines and Policy for Determination of Humane Endpoints for Animals Used in Research

The obligation to minimize or eliminate unnecessary pain and distress that animals may experience when used in research, research training, and biological testing activities is clearly stated in the USDA Animal Welfare Act and the PHS Policy on Humane Care and Use of Laboratory Animals. To that end, the Institutional Animal Care and Use Committee (IACUC) at the University of Virginia reviews all proposed and current animal use to ensure that we, as an institution, meet both our legal and ethical obligations with regard to animal research.