Non-invasive biomarkers of disease progression in mice with cancer are lacking, making it challenging to implement appropriate humane end points. The authors conclude that temperature, food and water consumption were useful biomarkers of disease progression in mice with lymphomas and could potentially be used more widely to monitor mice with other forms of cancer.
A sore system for the monitoring of mice initially published by the University of Virginia has been adapted and been modified by the Institut of Laboratory Animal Science of the University of Zurich. In particular the termination criteria have been reset to an earlier point.
The obligation to minimize or eliminate unnecessary pain and distress that animals may experience when used in research, research training, and biological testing activities is clearly stated in the USDA Animal Welfare Act and the PHS Policy on Humane Care and Use of Laboratory Animals. To that end, the Institutional Animal Care and Use Committee (IACUC) at the University of Virginia reviews all proposed and current animal use to ensure that we, as an institution, meet both our legal and ethical obligations with regard to animal research.